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Trichotillomania and Genetics

Gene Variation Could Explain Trichotillomania in Some Families

After researching 44 families in which one or more family members are trichsters, Duke University Hospital Scientists in Durham, North Carolina have discovered two mutations in a gene called SLITKR1.

Given the small number of families researched, it is hard to give exact figures but it is estimated that the SLITRK1 structural changes are present in perhaps five percent of trichsters, so this is by no means the answer we have been looking for, for most of us.

These findings do indicate a biological origin behind disorders like ours, yet it is wise to be wary of discounting the effect of our experiences and self-image, on our pulling, as well as the fact that many trichsters do not have either of these mutations of the SLITKR1 gene.

In 2005, this same SLITRK1 gene was connected with the more severe last impulse-control disorder, Tourettes, and there are a few families in which one person has Tourettes while another has trichotillomania.

Two mutations in the SLITRK1 gene were discovered in some individuals with trichotillomania but not shared by their non-trichster relations.

The SLITRK1 gene plays a part in bridging connections between brain cells, and it may be that in the split second before a connection is made, or while a connection is trying to be made, this electrical interruption causes an urge to pull out hair or eyelashes.

It is likely that a combination of genes and perhaps structural variations of genes contribute to the condition in most trichsters, but every discovery about the disorder is a step to unlocking a solution.

If you are interested in carrying out a research project and would like any help or involvement from us; please contact us. We are always happy to help improve knowledge of trichotillomania in any way we can.

Regarding your article on if trich is genetic, I would like to say that I am part of a family that I believe it to be in my genes. My mom's cousin began pulling when she was about 9 years old and she's now in her 50s still feeling that urge to pull. I had it triggered when I was 10. Though it is classified as OCD, ICD, addiction, self mutilation, etc., I strongly believe that the mutation is in my blood. And I fear it will pass on to other members. If it truly is genetic, I know I can't control this mutation from spreading through the bloodlines. But I would like to know if there's anymore research about this mutation". Jana Join the discussion